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DeFi Protocols Cheat Sheet

DeFi is traditional finance rebuilt on smart contracts. Hundreds of protocols compete across lending, trading, derivatives, and yield optimization. This cheat sheet maps the major protocols by category so you can quickly identify what each one does, which chain it runs on, and how it fits into the broader ecosystem.

Decentralized Exchanges (DEXs)

ProtocolChain(s)ModelKey Feature
UniswapEthereum, Polygon, Arbitrum, othersAMM (Automated Market Maker)Largest DEX by volume; concentrated liquidity in V3
Curve FinanceEthereum, multi-chainStableSwap AMMOptimized for stablecoin and pegged-asset swaps with minimal slippage
SushiSwapMulti-chainAMMUniswap fork with added yield farming incentives and cross-chain support
dYdXOwn L1 (Cosmos-based)Order BookPerpetual futures trading with up to 20x leverage
PancakeSwapBNB Chain, EthereumAMMLeading DEX on BNB Chain; lower gas fees than Ethereum-native DEXs

Lending and Borrowing

ProtocolChain(s)ModelKey Feature
AaveEthereum, Polygon, Arbitrum, othersPooled LendingFlash loans, variable/stable rates, governance via AAVE token
CompoundEthereumPooled LendingPioneer of algorithmic interest rates; cTokens represent deposits
MakerDAOEthereumCDP (Collateralized Debt Position)Issues DAI stablecoin against crypto collateral; the original DeFi protocol
MorphoEthereumPeer-to-Peer MatchingSits on top of Aave/Compound; matches lenders and borrowers for better rates
Spark (by MakerDAO)EthereumPooled LendingMaker’s lending arm focused on DAI-centric borrowing at low rates

Liquid Staking

ProtocolChain(s)Staked AssetKey Feature
LidoEthereumstETHLargest liquid staking protocol; stETH is widely accepted as DeFi collateral
Rocket PoolEthereumrETHDecentralized validator network; anyone can run a node with 8 ETH
Coinbase (cbETH)EthereumcbETHCentralized but highly liquid; popular with institutional investors
JitoSolanaJitoSOLLiquid staking on Solana with MEV rewards passed to stakers

Yield Aggregators

ProtocolChain(s)StrategyKey Feature
Yearn FinanceEthereum, multi-chainAutomated VaultsAuto-compounds yields across lending and LP strategies; “set and forget”
Convex FinanceEthereumCurve LP BoostingBoosts Curve LP rewards without locking CRV yourself; earns CVX rewards
Beefy FinanceMulti-chainAutomated VaultsMulti-chain yield optimizer; auto-compounds farm rewards across 20+ chains

Bridges and Cross-Chain

ProtocolSupported ChainsKey Feature
Wormhole20+ chainsGeneric message passing; broad chain support for tokens and NFTs
LayerZero30+ chainsOmnichain messaging protocol; enables cross-chain token standards (OFT)
Stargate15+ chainsUnified liquidity bridge built on LayerZero; instant finality transfers
Across ProtocolEthereum L2sOptimistic bridge with fast finality; relayers front capital for speed
Risk Warning
DeFi protocols carry smart contract risk, oracle manipulation risk, and governance attack risk. Even audited protocols have been exploited. Never allocate more to DeFi than you can afford to lose, and diversify across protocols to limit single-point-of-failure exposure.
Analyst Tip
Track TVL trends on DeFiLlama.com rather than relying on protocol-reported numbers. A protocol’s TVL declining while competitors grow is a major red flag — it often means yield is no longer competitive or trust is eroding. Also compare TVL to market cap — a protocol with $2B TVL and $200M market cap may be undervalued relative to one with $500M TVL and $5B market cap.

Key Takeaways

  • DeFi protocols fall into clear categories: DEXs, lending, staking, yield, and bridges
  • TVL is the primary adoption metric — but always compare TVL-to-market-cap ratios
  • Liquid staking (Lido, Rocket Pool) lets you earn staking yield while keeping capital deployable in DeFi
  • Yield aggregators auto-compound strategies but add another layer of smart contract risk
  • Cross-chain bridges are among the highest-risk DeFi primitives — billions have been lost to bridge exploits

Frequently Asked Questions

What is Total Value Locked (TVL) and why does it matter?

TVL measures the total dollar value of crypto assets deposited in a protocol’s smart contracts. Think of it as the DeFi equivalent of assets under management. Higher TVL generally indicates stronger adoption and deeper liquidity, but it can be inflated by recursive borrowing and should be cross-referenced with unique user counts.

What is the difference between an AMM and an order book DEX?

AMMs like Uniswap use liquidity pools and mathematical formulas to set prices automatically. Order book DEXs like dYdX match buyers and sellers at specific prices, similar to a traditional exchange. AMMs work better for long-tail tokens with fewer traders; order books offer tighter spreads for high-volume pairs.

How does liquid staking work?

You deposit ETH (or SOL, etc.) into a liquid staking protocol and receive a derivative token (stETH, rETH) in return. The protocol stakes your tokens and earns validator rewards. Your derivative token appreciates in value over time and can be used as collateral in DeFi — giving you staking yield plus DeFi composability.

Are DeFi yields sustainable?

Sustainable yields come from real economic activity: trading fees (DEXs), interest from borrowers (lending), and network staking rewards. Token emission rewards (governance token farming) are temporary and inflationary. Focus on protocols where the majority of yield comes from fees, not emissions.

What is the biggest risk in DeFi?

Smart contract risk — a bug or exploit in the protocol’s code can drain all deposited funds. Cross-chain bridges have been particularly vulnerable, with over $2 billion lost to bridge exploits since 2021. Other risks include oracle manipulation, governance attacks, and regulatory uncertainty. Diversification across protocols and chains is essential.